Yoitsu is located to the far north, west of Nyohhira amidst the Roef Mountains, and is the home to Holo and several other wolves like her. This was the primary destination for Holo until she and Lawrence fell in love with each other.
According to Holo, Yoitsu's geography is similar to the taiga (the northern forests of Europe, Siberia and North America), with short summers and long winters. The trees in this land are so massive that they can support Holo's weight and size in her full wolf form.
As seen in a flashback, this is also the home of other giant wolves. However, it is never confirmed whether they too are deities or not.